Tilapia is fast becoming one of America’s most popular types of fish. And it’s easy to see why. Tilapia is a mild fish that can be prepared in dozens of different ways.

In this incredibly easy Cajun-spiced tilapia recipe, the fish is rubbed with a store-bought Cajun seasoning, then sauteed in a little butter or margarine, and topped with salsa. You can use your own homemade tomato salsa or cucumber tomato salsa, or your favorite store-bought salsa.

If you are planning to use a store-bought salsa, get a mild one, as the salsa is the cooling agent in this tilapia fish dish.


Sauteed Cajun Tilapia


  • 4 tilapia fish fillets (about 1-1/2 pounds)
  • 2 Tbsp. Cajun seasoning
  • 2 Tbsp. butter or trans fat-free margarine
  • 1/2 cup salsa


  1. Rub Cajun seasoning all over both sides of the fish fillets. Set aside.
  2. Heat a large (12- or 14-inch) skillet over medium heat. Melt butter in skillet.
  3. Add tilapia fillets, cooking until lightly browned and cooked through, about 2-3 minutes on each side.
  4. Remove tilapia fillets to a serving platter. Top with salsa.

Serve immediately.

Makes 4 servings.

Per serving: 180 calories, 8 g fat (5 g saturated fat), 78 mg cholesterol, 261 mg sodium, 2 g carbohydrate, 1 g fiber, 26 g protein, 5% vitamin A, 1% vitamin C, 2% calcium, 5% iron